hen I was just a little postdoc, my comrades thought of pharmacology
as the lowliest of sciences because it consisted, in their view, of
buying or making chemicals and throwing them at diseases. Immunology,
too, was trivial: give the rabbit an antigen, and voilà: you
get an antibody. Easy peasy.
No doubt immunologists and DNA cloning people thought the same of us, slaving away as we were studying passive globs of amino acids whose only value is as something to immunize somebody with. But everyone agreed that pharmacology is the easiest science because it consisted of using a gigantic high-throughput machine to discover molecules by brute force instead of using logic to find answers.
So it shouldn't come as a big surprise that lo and behold, when the world came to the pharmacologists at Big Pharma to save them from a virus, we ended up with a monstrosity.
There is no such thing as a passive protein. One of the few mandatory training courses they give us that's actually useful is the one on biohazards, where they tell us we're forbidden to do things like putting diphtheria toxin in an expression vector. Diphtheria toxin is the most toxic substance known to man: a single molecule of it will kill a cell. Other bacteria produce toxins like Shiga toxin, anthrax toxin, and cholera toxin. They're all proteins. Viruses cause the cell to produce toxins for them, but they're just as toxic. If a vector with one of these toxins got loose, it would be a bad thing.
So Big Pharma, thinking immunology was easy, naturally thought it would be a wonderful idea to use the full-length sequence for a protein known to be poisonous as the active component of their vaccine. And what is worse, put it in their new expression vector and engineer it to be expressed at high levels for as long as possible to get a really big immune response.
As I warned about here, the Spike protein is what makes Covid so deadly. It's like injecting botulinum toxin to protect against botulinum toxin.
The fact that people were getting a massive rash that covered their upper arm should have been a clue that it was making far too much antigen. As a result, patients with weak immune systems were saved, and patients with strong immune systems got side effects. With repeated boosters, the immune system went haywire and patients paradoxically lost all resistance to Covid. The result is that some people thought the vax was perfectly safe and others thought it was a public health catastrophe.
What is an expression vector?
An expression vector is usually a big circular piece of DNA that contains the sequence for a protein. There are mammalian expression vectors, which express a protein in mammalian cells, as well as bacterial ones. Each has a special sequence that determines what, where, and how fast the protein is expressed. Messenger RNA (mRNA) can be thought of as a expression vector because it too is expressed, but mRNA is far less sophisticated than the DNA expression vectors because it can't be tailored to turn on and off at will.
A simple plasmid vector map. This is a mammalian expression vector that will express the gene marked "protein" along with EGFP, a green fluorescent protein that scientists use to detect whether the protein is fully expressed in their cells. It's a mature technology
Some skeptics call the mRNA vax a gene therapy. It's not, because mRNA is not a gene and it doesn't integrate in the genome. Not everything with a coding sequence is a gene, and those who call Pfizer's Covid vax a form of gene therapy make themselves look uneducated by calling it that.
But it is an expression vector, and it's a crude one because once it's in your cells the only way to turn it off is by degrading it. And that's a big problem: the dose of an antigen makes a huge difference to the patient. A moderate dose of the flu vaccine has no discernible effect, while doubling the dose can cause lymphadenopathy and a week of misery. With a big enough dose, the immune system goes into a panic, as if it's thinking, “Oh my God, I must have a massive infection!” And so it ignores the other things, like other infections, different versions of the same virus, and early cancer in a desperate attempt to save your life.
When you vaccinate a patient, their immune system uses a type of directed evolution to create new antibodies. Antibody maturation sounds complicated, and it is, but it is also a fascinating process of rapid cell-based directed Darwinian evolution which is briefly described here. I suspect that the side-effects some people are experiencing are caused in part by the massive dose the vector is giving them.
Did Pfizer even do a dose-response experiment in humans? Did they even do a Phase I trial? If they did, we never heard about it. Even we lowly molecular biologists know that a high enough dose will turn anything, even water, into a poison.
Pfizer channels Wuhan Institute of Virology
Whatever happened to ‘personalized medicine’? We were supposed to be moving toward treatments tailored to each individual. Instead we got the opposite: everyone gets the same massive dose of a toxic antigen. Those with weak immune systems are protected, at least for a while, and they have few side effects, and those with strong ones get killed off. Those are the very people we need the most: the ones whose immune systems are strong enough to help humanity survive the next plague, like Charlton Heston in The Omega Man, which will certainly be far more dangerous than Covid ever was.
How do I know this? From a report of an interview from Project Veritas with Jordon Trishton Walker, a soon to be former director of research and development at Pfizer. Walker was reported as saying that his company thinks using directed evolution to create new, more deadly viruses would be a “cash cow”:
One of the things we [Pfizer] are exploring is like, why don't we just mutate it [COVID] ourselves so we could create -- preemptively develop new vaccines, right? So, we have to do that. . . .
Promise you won't tell anyone. The way it would work is that we put the virus in monkeys, and we successively cause them to keep infecting each other, and we collect serial samples from them.
When I read this, I sighed and said “These guys have no clue what they're doing.”
Whether it's true or not, it sounds like another example of Big Pharma going wildly out of control. But what's really happening is that people in different branches of science, in this case pharmacology, immunology, protein biochemistry, and virology, not understanding the other, thinking the others' subject is easy and trivial. The military calls it stovepiping. It can be just as deadly in medicine as in the military.
jan 26 2023, 6:05 am
